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缺血组织再灌注时产生的氧自由基是缺血性损伤和组织坏死的重要原因。本文综述再灌注时氧自由基产生的各种学说以及为消除其有害作用进行的实验研究,阐述了再灌注损伤的机理、氧自由基的来源及自由基清除剂的作用。对断肢再植后的“无回流现象”作出了可能的解释。
Oxygen free radicals produced during ischemia reperfusion are important causes of ischemic injury and tissue necrosis. This article reviews various theories of oxygen free radicals during reperfusion and experimental studies to eliminate their deleterious effects. The mechanism of reperfusion injury, the origin of oxygen free radicals and the role of free radical scavengers are elucidated. Possible explanations for the “no-reflow phenomenon” after replantation of severed limbs.