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目的：研究黄芪总黄酮对失血性休克再灌注肝损伤的防护作用。方法：用家兔为实验对象，观察失血性休克再灌注后３０ｍｉｎ、２ｈ、６ｈ、２４ｈ转氨酶（ＧＰＴ、ＧＯＴ）和血气指标（ｐＨ、ＰＣＯ２、ＰＯ２、ＨＣＯ－３、ＴＣＯ２、ＳＢＣ）的改变以及滴注黄芪总黄酮（ＴＦＡ）后的影响。结果：失血性休克再灌注后２４ｈ血浆ＧＰＴ、ＧＯＴ值升高明显，血气指标发生改变，而滴注ＴＦＡ后可有效抑制因缺血再灌注引起的ＧＰＴ、ＧＯＴ的升高，血气指标的变化明显改善。结论：ＴＦＡ作为一种抗氧化剂对失血性休克再灌注所致肝损伤有防护作用。
Objective: To study the protective effect of total flavonoids from Astragalus on liver injury after hemorrhagic shock and reperfusion. METHODS: Rabbits were used as experimental subjects to observe changes in transaminase (GPT, GOT) and blood gas parameters (pH, PCO2, PO2, HCO-3, TCO2, SBC) at 30 min, 2 h, 6 h, and 24 h after hemorrhagic shock. Effects of total flavonoids (TFA) after instillation of Astragalus membranaceus. RESULTS: Plasma GPT and GOT values increased significantly after hemorrhagic shock 24 hours after reperfusion, and blood gas indexes changed. Intravenous instillation of TFA could effectively inhibit the increase of GPT and GOT caused by ischemia-reperfusion, and the change of blood gas index was significant. improve. Conclusion: As an antioxidant, TFA has a protective effect on hepatic injury induced by hemorrhagic shock and reperfusion.