Advanced digestive tract malignant tumors, represented by advanced colorectal cancer, advanced gastric cancer and advanced esophageal cancer, have insidious onsets and high mortality. Western medicine based on targeted therapy greatly can improves the benefit and efficacy for patients through population stratification, but its population is limited. Traditional Chinese medicine (TCM) has a long history in treatment of tumors, which is an important part of comprehensive treatment of tumors. Clinical observation has shown that different patients could get different efficacy from TCM treatment. Based on real world registration studies, patients with advanced colorectal cancer, advanced gastric cancer or advanced esophageal cancer who had received TCM treatment were observed and followed, and a TCM dominant population that achieved significant efficacy was screened out to carry out multivariate regression analysis, further explore key factors that affect survival in advanced digestive tract malignant tumors, and establish a prediction model of TCM dominant population. It will provide reference for the follow-up TCM treatment, and provide reference for development of individualized treatment plans, making the TCM treatment for advanced digestive tract malignant tumors more targeted, and helping to improve the benefit rate in TCM.