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目的 分析合并代谢综合征及其组分的甲状腺乳头状癌患者复发特点。方法 回顾性分析郑州大学第一附属医院2010年1月1日至2015年12月31日，于甲状腺外科初次手术后复发的甲状腺乳头状癌患者。比较伴与不伴代谢异常的复发甲状腺乳头状癌的结节大小、淋巴结转移分区、复发时间及术后浸润机率之间的差异。结果 82例复发甲状腺乳头状癌中，男性34例，女性48例，经典代谢综合征分组方法下的两组差异无统计学意义。当以同时合并2个以上代谢异常为依据分组时，发现代谢综合征组初发时淋巴结转移分级较低，尤其以女性患者显著(P=0.002)，而且复发时间较短，男性有统计学意义(P=0.036)；分析合并单一代谢异常组分者，男性患者复发时间较短(P血糖=0.034，P血脂=0.037， PBMI=0.004)。结论 合并代谢异常的甲状腺乳头状癌患者，尤其是同时合并2种以上代谢综合征组分，或超重肥胖的患者，甲状腺癌复发风险增加。
Objective To analyze the recurrence characteristics of thyroid papillary carcinoma with metabolic syndrome and its components. Methods A retrospective analysis of the first Affiliated Hospital of Zhengzhou University from January 1, 2010 to December 31, 2015 in thyroid surgery after the first recurrence of thyroid papillary carcinoma patients. The differences of nodule size, lymph node metastasis, recurrence time and the rate of postoperative infiltration were compared between papillary thyroid carcinoma with or without metabolic abnormalities. Results 82 cases of recurrent thyroid papillary carcinoma, 34 males and 48 females, classic metabolic syndrome grouping two groups, the difference was not statistically significant. When combined with more than two metabolic abnormalities at the same time as the basis for grouping, we found that the metabolic syndrome group at the time of initial lymph node metastasis grading, especially in female patients was significantly (P = 0.002), and the recurrence time was shorter, the male was statistically significant (P = .036). The analysis of patients with single metabolic abnormalities was shorter in male patients (P glucose = 0.034, P lipid = 0.037, PBMI = 0.004). Conclusions Patients with thyroid papillary carcinoma with metabolic abnormalities, especially those with more than two metabolic syndrome components or overweight and obesity, have an increased risk of thyroid cancer recurrence.