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目的:探讨外阴湿疣及宫颈炎症与宫颈HPV亚临床感染(SPI)的关系以及SPI与高危型HPV DNA感染的相关性。方法:对169例研究对象进行基本情况问卷调查,通过宫颈液基细胞检查、阴道镜检查及阴道镜下取组织进行病理诊断,或术后宫颈病理检查,判定有无SPI感染。通过杂交捕获试验Ⅱ检测高危型HPV DNA感染。结果:宫颈SPI的检出率为外阴湿疣组53.1%,宫颈糜烂组为22.7%(P<0.05);97例宫颈糜烂患者中,Ⅰ、Ⅱ、Ⅲ度患者的PSI感染率有逐渐上升趋势,但三者差异无显著性(P>0.05);单纯型、颗粒型、乳头型宫颈糜烂组SPI感染率分别为20.0%、23.4%、22.5%,颗粒型和乳头型糜烂中的SPI感染率略高于单纯型,但三者差异无显著性(P>0.05)。高危HPV DNA的检出率为外阴湿疣组41.7%、宫颈糜烂组为28.7%、正常对照组为8.3%。与正常对照组比较,实验组高危HPV DNA检出率明显提高(P<0.01);宫颈糜烂组与外阴湿疣组比较,高危HPV DNA检出率无统计学意义(P>0.05)。高危型HPV DNA检出率在SPI阳性病例与阴性病例中的检出率分别为69.2%和7.8%,SPI阳性病例与阴性病例比较,高危型HPV DNA检出率明显提高(P<0.01)。结论:外阴湿疣、宫颈炎症患者是宫颈SPI的高危人群,且SPI病例中高危HPV DNA的检出率高于非SPI病例,应重点随访和管理。
Objective: To investigate the relationship between genital warts and cervical inflammation and cervical HPV subclinical infection (SPI) and the relationship between SPI and high-risk HPV DNA infection. Methods: A total of 169 subjects were surveyed by questionnaire. The cervical lymphocytes were examined by liquid-based cervical cytology, colposcopy and colposcopy under pathological examination, or postoperative cervical pathological examination to determine whether there was any SPI infection. Capture Ⅱ Test by Hybridization to Detect High Risk HPV DNA Infection. Results: The detection rate of cervical spondylosis was 53.1% in genital warts group and 22.7% in cervical erosion group (P0.05). In 97 cases of cervical erosion patients, the infection rates of PSI in Ⅰ, Ⅱ and Ⅲ degree patients increased gradually, But there was no significant difference among the three groups (P> 0.05). The infection rates of SPI in simple, granular and papillary cervical erosion group were 20.0%, 23.4% and 22.5%, respectively. The infection rates of SPI in granular and papillary erosion Higher than the simple type, but the difference was not significant (P> 0.05). The detection rate of high-risk HPV DNA was 41.7% in genital warts group, 28.7% in cervical erosion group and 8.3% in normal control group. Compared with the normal control group, the detection rate of high-risk HPV DNA in the experimental group was significantly increased (P <0.01). Compared with the vulvar condyloma group, the detection rate of high-risk HPV DNA was not statistically significant (P> 0.05). The detection rate of high-risk HPV DNA was 69.2% and 7.8% respectively in SPI-positive cases and negative cases. The detection rate of high-risk HPV DNA was significantly higher in SPI-positive cases than in negative cases (P <0.01). Conclusions: Genital warts and cervicitis patients are at high risk of cervical SPI, and the detection rate of high-risk HPV DNA in SPI cases is higher than that of non-SPI cases, and should be followed up and managed.