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一些作者认为肺功能异常与胃食管返流(GER)之间有关联。这一观点经对返流者作手术或药物治疗后哮喘持续状态得以减轻甚至消失的报告而得到支持。为确定哮喘患者的GER发生率和检出其特征,24小时食管pH监测对哮喘者出现GER的机制有两种不同的假设:(a)微量胃内容物吸入肺部而引起粘膜渗出性反应;(b)GER激活食管至肺的迷走神经反射弧导致支气管收缩。
Some authors believe that there is a correlation between lung dysfunction and gastroesophageal reflux (GER). This view is supported by reports that the status of asthma relief has diminished or even disappeared after surgery or medical treatment of the returnees. There are two different hypotheses regarding the mechanism of 24-hour esophageal pH monitoring for the presence of GER in asthmatics in order to determine the incidence of GER in asthmatics and their characteristics: (a) trace amounts of gastric contents aspirate into the lungs causing mucosal exudative response ; (b) GER activates the vagal reflex arc of the esophagus to the lung leading to bronchoconstriction.