论文部分内容阅读
目的:研究GSTM1、GSTT1基因多态性与乳腺癌遗传易感性的关系。方法:应用PCR技术检测乳腺癌组和对照组人群GSTM1和GST T1基因。结果:GSTM 1和GSTT 1基因缺失率在乳腺癌组分别为63.4%(59/93)和54.8%(51/93),对照组分别为39.3%(35/89)和33.7%(30/89),两组比较,差异有统计学意义(P<0.01或P<0.05)。结论:GSTM1和GST T1缺失为乳腺癌遗传易感因素。
Objective: To investigate the relationship between genetic polymorphisms of GSTM1 and GSTT1 and genetic predisposition of breast cancer. Methods: The GSTM1 and GST T1 genes in breast cancer and control subjects were detected by PCR. RESULTS: The deletion rates of GSTM 1 and GSTT 1 genes in breast cancer patients were 63.4% (59/93) and 54.8% (51/93) respectively, while those in control group were 39.3% (35/89) and 33.7% (30/89) respectively ), The difference between the two groups was statistically significant (P <0.01 or P <0.05). Conclusions: The deletion of GSTM1 and GST T1 is a predisposing factor for breast cancer.