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目的:观察B型心钠素测定在青南地区海拔3 000m以上藏族人群中慢性肺源性心脏病心衰的临床意义。方法:采用放射免疫法测定治疗前血浆B型心钠素水平,给予吸氧、抗感染、强心利尿、血管活性药物等,心衰纠正后再次测定血浆B型心钠素。结果:青南高海拔地区藏族肺心病心衰患者外周静脉血B型心钠素含量(173.46±28.14)Pg/mL明显高于治疗后(94.50±21.43)Pg/mL,(P<0.001)。结论:心钠素有助于判断高海拔地区肺心病心衰的程度。
Objective: To observe the clinical significance of type B atrial natriuretic peptide in the diagnosis of heart failure of chronic cor pulmonale in Tibetan population above 3000m in Qingnan area. Methods: Plasma B-type atrial natriuretic peptide level before treatment was measured by radioimmunoassay. Oxygen inhalation, anti-infective, cardiac diuretic, vasoactive drugs were given. Plasma B-type natriuretic peptide was measured again after correction of heart failure. Results: The plasma BNP (173.46 ± 28.14) Pg / mL in peripheral venous blood was significantly higher in Tibetan patients with cor pulmonale at high altitudes than that at 94.50 ± 21.43 (P <0.001) after treatment. Conclusion: Atrial natriuretic peptide can help determine the severity of heart failure in high altitude areas.