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目的:探讨含有透明细胞胃癌的临床病理意义。方法:26例含有透明细胞胃癌手术标本分别进行光镜、电镜观察及组织化学、ABC法免疫组化染色。2例妊娠3月胎儿胃肠标本作对照。结果:含有透明细胞胃癌均为进展期癌,组织学主要有2种类型:不同分化程度的乳头状管状腺癌及肝样腺癌,18例(76.92％)见淋巴管癌栓,5例(19.23％)见静脉癌栓;淋巴结及肝转移率高(88.46％,11.54％),5年生存率为9.1％。透明细胞AB染色阴性,PAS染色少部分阳性。电镜见胞质中含有丰富的糖原颗粒。AFP、AAT和HCG阳性率分别为64.71％、76.47％和58.82％。结论::含有透明细胞胃癌属于产生AFP并伴胎儿肠胚分化腺癌及肝样腺癌,恶性程度高,预后差。
Objective: To investigate the clinicopathological significance of clear cell gastric cancer. Methods: Twenty-six cases of gastric cancer with clear cell were stained with light microscopy, electron microscopy and histochemical staining respectively. 2 cases of pregnancy fetus gastrointestinal specimens as a control. Results: There were 2 types of histology including clear cell carcinoma of the stomach, histological changes of papillary thyroid carcinoma and hepatic adenocarcinoma, 18 cases (76.92%) of lymphatic tumor thrombus and 5 cases of 19.23%) had a tumor thrombus in the vein. The rate of lymph node and liver metastasis was high (88.46%, 11.54%) and the 5-year survival rate was 9.1%. Transparent cells were negative for AB staining and less positive for PAS staining. Electron microscopy see the cytoplasm is rich in glycogen particles. The positive rates of AFP, AAT and HCG were 64.71%, 76.47% and 58.82% respectively. CONCLUSION :: Containing clear cell carcinoma of the stomach belongs to the generation of AFP with fetal enterocolitis and adenocarcinoma of the liver, with a high degree of malignancy and poor prognosis.