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目的观察阿仑膦酸钠与替勃龙联用对绝经后骨质疏松症(PMOP)患者骨密度(BMD)和骨代谢的影响。方法将PMOP患者163例随机分为2组,观察组81例给予阿仑膦酸钠、替勃龙及维D钙咀嚼片治疗;对照组82例给予阿仑膦酸钠、安慰剂及维D钙咀嚼治疗,2组疗程均为6个月。比较2组疗效,检测2组治疗前后的BMD。结果观察组总有效率为87.65%高于对照组的60.98%,差异有统计学意义(P<0.05)。治疗前2组腰椎正位、胫骨颈、大粗隆及Ward’s三角区BMD比较差异无统计学意义(P>0.05),治疗后6个月2组均升高(P<0.05),且观察组高于对照组(P<0.05)。结论阿仑膦酸钠与替勃龙联用可明显提高PMOP患者的BMD,值得临床推广应用。
Objective To observe the effect of alendronate and tibolone on bone mineral density (BMD) and bone metabolism in patients with postmenopausal osteoporosis (PMOP). Methods 163 patients with PMOP were randomly divided into two groups. The observation group was given alendronate, tibolone and vitamin D calcium chewable tablets. The control group was given alendronate, placebo and vitamin D Calcium chewing treatment, two groups of treatment were 6 months. The curative effect of two groups were compared, BMD of two groups before and after treatment were detected. Results The total effective rate of the observation group was 87.65% higher than that of the control group (60.98%), the difference was statistically significant (P <0.05). There was no significant difference in BMD between antegrade, tibial neck, greater trochanter and Ward’s triangle before treatment (P> 0.05) Higher than the control group (P <0.05). Conclusion The combination of alendronate and tibolone can significantly improve the BMD of patients with PMOP, which is worthy of clinical application.