胃细胞逆转丸治疗胃癌前期病变的临床与实验研究

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目的观察胃细胞逆转丸对胃癌前期病变的治疗效果.方法选择36例胃癌前期病变患者应用胃细胞逆转丸(主要由党参,丹参,大黄,黄连等15味中药组成)进行治疗,其中轻度萎缩性胃炎13例(361%),中度萎缩性胃炎14例(389%),重度萎缩性胃炎9例(250%),伴肠上皮化生者22例(611%),异型增生者27例(750%).男20例,女16例,年龄30岁~67岁,其中40岁~59岁者22例(611%).病程3个月~21年,其中5年~10年者20例(556%).临床表现为痞满31例,疼痛27例,纳呆30例,嗳气26例,泛酸6例,便溏9例.3个月1疗程.疗程结束后,对患者的临床症状、胃粘膜的萎缩、肠上皮化生、异型增生改善情况进行分析.结果经胃细胞逆转丸治疗3个月后,临床症状痊愈7例,显效11例,好转13例,无效5例,总有效率为861%.13例轻度萎缩性胃炎中11例转为浅表性胃炎,2例无变化;14例中度萎缩性胃炎中有4例转为浅表性胃炎,7例转为轻度萎缩性胃炎,3例无变化;9例重度萎缩性胃炎中有5例转为中度萎缩性胃炎,4例无变化,慢性萎缩性胃炎总有效率为778%.9例轻度肠上皮化生消失6例,无变化3例;1? 3. Objective To observe the therapeutic effect of gastric cell reverse pill on precancerous lesions of gastric carcinoma. Methods Thirty-six patients with precancerous lesions were treated with gastric cell reversal pills (mainly composed of 15 Chinese herbal medicines, including Dangshen, Salvia miltiorrhiza, rhubarb, and berberine). Among them, 13 cases (36.1%) of mild atrophic gastritis, moderate atrophy. Gastritis in 14 cases (38.9%), severe atrophic gastritis in 9 cases (25.0%), intestinal metaplasia in 22 cases (61.1%), dysplasia in 27 cases (75.0%). . There were 20 males and 16 females, aged from 30 to 67 years, of whom 22 were from 40 to 59 years old (61.1%). Duration of 3 months to 21 years, of which 5 to 10 years were 20 cases (55.6%). The clinical manifestations were indwelling 31 cases, 27 cases of pain, 30 cases of poor appetite, 26 cases of hernia, 6 cases of pantothenic acid, 9 cases of loose stools. 3 months 1 course of treatment. At the end of the treatment period, the clinical symptoms, gastric mucosal atrophy, intestinal metaplasia, and dysplasia were analyzed. Results After 3 months of gastric cell reversal pill treatment, clinical symptoms were cured in 7 cases, markedly in 11 cases, improved in 13 cases, and ineffective in 5 cases. The total effective rate was 86.1%. Among 13 cases of mild atrophic gastritis, 11 cases turned to superficial gastritis, 2 cases had no change; 4 cases of moderate atrophic gastritis turned to superficial gastritis, 7 cases turned to mild atrophic gastritis, There were no changes in 3 cases; 9 cases of severe atrophic gastritis were converted to moderate atrophic gastritis, 4 cases were unchanged, and the total effective rate of chronic atrophic gastritis was 77.8%. 9 cases of mild intestinal metaplasia disappeared in 6 cases, no change in 3 cases; 1?
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