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目的:分析比较腹腔镜和开腹结直肠癌根治术两种术式对结直肠癌患者肠道屏障功能的影响。方法:2015年1月至2016年10月在我院行结直肠癌手术患者共62例，随机分成腹腔镜组34例和开腹组28例。比较两组患者术后肠屏障功能的变化情况。结果:观察组术后第1、3、5、7天血浆D-乳酸、血浆二胺氧化酶、细菌内毒素水平均低于对照组(n P均<0.05)。n 结论:腹腔镜与开腹结直肠癌手术对肠道屏障功能都会造成损伤；腹腔镜结直肠癌手术对肠道屏障功能的损伤较开腹结直肠癌手术轻。“,”Objective:To compare and investigate the effects of laparoscopy and open colorectal cancer on the intestinal barrier function in patients with colorectal cancer.Methods:Sixty-two patients with colorectal cancer admitted in our hospital from January 2015 to October 2016 were selected and divided into laparoscopic surgery group with thirty-four patients and open surgery group with twenty-eight patients. The changes of postoperative intestinal barrier function were compared between the two groups.Result:The levels of plasma D-lactate, plasma diamine oxidase (DAO) and bacterial endotoxin in the laparoscopic surgery group were significantly lower than those in the open surgery group (n P<0.05).n Conclusion:Laparoscopic and open colorectal cancer surgery can cause damage to intestinal barrier function, but the damage of laparoscopic colorectal cancer surgery is lower than that of open colorectal surgery.