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目的 预测化疗所致粒细胞缺乏症患者医院感染发生的危险因素。方法 对 345例因化疗所致粒细胞缺乏症患者医院感染进行回顾性调查 ,用多因素 Cox模型分析 16个可能对医院感染产生影响的危险因素。结果 年龄、粒细胞缺乏程度、低粒细胞持续时间、化疗周期和预防使用粒细胞集落刺激因子 (CSF)对医院感染的发生有显著意义 (P<0 .0 5 )。结论 对高危患者应采取积极有效的预防措施 ,有助于降低感染率和病死率
Objective To predict the risk factors of nosocomial infection in patients with chemotherapy-induced agranulocytosis. Methods A retrospective study was performed on 345 cases of nosocomial infections in patients with agranulocytosis due to chemotherapy, and 16 risk factors influencing nosocomial infections were analyzed by multivariate Cox model. Results Age, the degree of agranulocytosis, the duration of neutrophils, the duration of chemotherapy, and the prevention of granulocyte colony stimulating factor (CSF) were significantly associated with nosocomial infections (P <0.05). Conclusions Positive and effective preventive measures should be taken for high-risk patients to reduce the infection rate and mortality rate