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目的:探讨缺血性脑血管病患者行脑血管支架置入术（VAS）后发生支架内再狭窄（ISR）的危险因素。方法:检索中国知网、维普、万方、中国生物医学文献数据库、PubMed、Embase、Cochrane Library数据库中关于缺血性脑血管病患者VAS术后ISR发生危险因素的病例对照研究和队列研究，检索时限均为各数据库建库截至2021年5月31日。2名研究者筛选文献并提取相关数据，采用卡尔斯-渥太华量表进行文献质量评价，采用RevMan 5.3软件进行Meta分析。结果:共纳入30篇研究。Meta分析结果显示，吸烟[n OR=3.76，95%置信区间（n CI）：2.43~5.82，n P<0.01]、糖尿病（n OR=2.95，95%n CI：2.15~4.06，n P<0.01）、高血压病（n OR=2.55，95%n CI：1.50~4.34，n P=0.006）、高脂血症（n OR=7.12，95%n CI：3.46~14.68，n P<0.01）、冠心病（n OR=3.06，95%n CI：1.10~8.47，n P=0.03）、同型半胱氨酸（n OR=2.36，95%n CI：1.30~4.27，n P=0.05）、氯吡格雷药物相关基因（n CYP2C19）突变（n OR=3.04，95%n CI：1.63~5.68，n P=0.05）、病变血管直径（n OR=3.43，95%n CI：1.30~9.05，n P=0.01）、残余狭窄（n OR=6.08，95%n CI：3.28~14.07，n P<0.01）、支架类型（n OR=2.26，95%n CI：1.18~4.36，n P=0.01）、支架长度（n OR=3.52，95%n CI：2.34~5.30，n P<0.01）与缺血性脑血管病患者VAS术后发生ISR有关。n 结论:缺血性脑血管病患者术后吸烟、有糖尿病史、高血压病史、高脂血症史、冠心病史、高水平同型半胱氨酸、n CYP2C19突变、病变血管直径较短、术后存在残余狭窄、使用金属裸支架、支架长度较长是VAS术后发生ISR的危险因素。临床医护人员应根据危险因素调整术后患者的随访时间、制订个性化策略预防ISR的发生。n “,”Objective:To explore risk factors of in-stent restenosis (ISR) after vertebral artery stenting (VAS) in patients with ischemic cerebrovascular disease.Methods:Case-control studies and cohort studies on risk factors for ISR after VAS in patients with ischemic cerebrovascular disease were searched from CNKI, VIP, Wanfang, Chinese Biomedical literature Database, PubMed, Embase and Cochrane Library. The retrieval time limit was the establishment of each database until May 31, 2021. Two researchers screened the literature and extracted relevant data. Newcastle-Ottawa Scale (NOS) was used to evaluate quality of the literature and RevMan 5.3 software was used for meta-analysis.Results:A total of 30 studies were included. Meta-analysis results showed that smoking [n OR=3.76, 95% confidence interval (n CI) : 2.43-5.82, n P<0.01], diabetes (n OR=2.95, 95%n CI: 2.15-4.06, n P<0.01) , hypertension (n OR=2.55, 95%n CI: 1.50-4.34, n P=0.006) , hyperlipidemia (n OR=7.12, 95%n CI: 3.46-14.68, n P<0.01) , coronary heart disease (n OR=3.06, 95%n CI: 1.10-8.47, n P=0.03) , homocysteine (n OR=2.36, 95%n CI: 1.30-4.27, n P=0.005) , clopidogrel drug-related gene (n CYP2C19) mutation (n OR=3.04, 95%n CI: 1.63-5.68, n P=0.005) , lesion vessel diameter (n OR=3.43, 95%n CI: 1.30-9.05, n P=0.01) , residual stenosis (n OR=6.08, 95%n CI: 3.28-14.07, n P<0.01) ) , stent type (n OR=2.26, 95%n CI: 1.18-4.36, n P=0.01) , stent length (n OR=3.52, 95%n CI: 2.34-5.30, n P<0.01) were associated with ISR after VAS operation in patients with ischemic cerebrovascular disease.n Conclusions:Postoperative smoking, history of diabetes mellitus, history of hypertension, history of hyperlipidemia, history of coronary heart disease, high level of homocysteine, n CYP2C19 mutation, shorter lesion vessel diameter, postoperative residual stenosis, use of bare metal stents and longer stent length are risk factors for ISR after VAS in patients with ischemic cerebrovascular disease. Clinical medical staff should adjust the follow-up time of postoperative patients according to risk factors and formulate individualized strategies to prevent the occurrence of ISR.n