微管在有丝分裂中扮演着重要的角色,微管靶点药物是抗肿瘤药物的重要组成部分。很多天然产物能作用于微管的不同部位,其中包括紫杉醇类和长春花碱类。根据这些天然产物对微管蛋白聚合所起的促进作用或抑制作用,将其划分成两类,着重讨论它们的来源、作用机制和生物活性。 Microtubules play an important role in mitosis, and microtubule targeting drugs are an important part of antitumor drugs. Many natural products can act on different parts of the microtubules, including paclitaxel and vinca alkaloids. Based on their promotion or inhibition of tubulin polymerization, these natural products are divided into two groups, focusing on their origin, mechanism of action and biological activity.