Samples Ag/O/S, Ag/O/Se and Ag/S/Se were ablated directly by laser to produce clusters. The detection was performed with a time-of-flight mass spectrometer (TOF MS). The cluster ions produced had the following distribution: Ag/S binary cluster ions for sample Ag/O/S, Ag/Se binary cluster ions for sample Ag/O/Se, and Ag/Se binary cluster ions and Ag/S/Se ternary cluster ions as the main products for sample Ag/S/Se. Laser double ablation reactor was used to study the reaction between Ag/S(Se, O) binary clusters and Se(S) homoclusters. The experiments show that Se clusters can replace S and O in Ag/S and Ag/O clusters while S clusters can replace O in Ag/O clusters. This fact indicates the sequence of the clustering ability of Ag presented as follows: Ag/Se > Ag/S > Ag/O, which was also proved by theoretical calculation. The reason of this tendency was considered to be the different abilities of the elements’ polarization, which acts on the stability of clusters. Samples Ag / O / S, Ag / O / Se and Ag / S / Se were ablated directly by laser to produce clusters. The detection was performed with a time-of-flight mass spectrometer (TOF MS). The cluster ions produced had the following distribution: Ag / S binary cluster ions for sample Ag / O / S, Ag / Se binary cluster ions for sample Ag / O / Se, and Ag / Se binary cluster ions and Ag / S / The main products for sample Ag / S / Se. Laser double ablation reactor was used to study the reaction between Ag / S (Se, O) binary clusters and Se (S) homoclusters. The experiments show that Se clusters can replace S and O in Ag / S and Ag / O clusters while S clusters can replace O in Ag / O clusters. This fact indicates the sequence of the clustering ability of Ag presented as follows: Ag / Se> Ag / S> Ag / O, which was also proved by theoretical calculation. The reason of this tendency was considered to be the different abilities of the elements’ polarization, which acts on the stability of clusters.