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目的 比较光学相干断层成像术 (OCT)测量视网膜神经纤维层 (RNFL)厚度与图形视网膜电图 (PERG)在开角型青光眼诊断与监测中的应用。方法 采用配对研究 ,同时对 2 6例(5 0眼 )开角型青光眼患者进行OCT与PERG检查 ,配对 χ2 检验比较二种检查在青光眼中的异常率 ,线性回归分析其间相关性。结果 青光眼环绕视乳头的RNFL平均厚度以及上、下象限的RNFL厚度与PERG振幅呈显著性相关 (P <0 0 5 )。OCT与PERG检查在青光眼早期中的异常率分别为 40 9%与 77 9% ,差异具有显著性意义 (P <0 0 5 ) ;在进展期与晚期中的异常率分别为 78 6%与 82 1% ,差异无显著性。结论 在青光眼的早期诊断中 ,OCT的敏感性低于PERG ;在进展期与晚期 ,OCT与PERG的敏感性无显著性差异。联合检查将则更有助于开角型青光眼的早期诊断与监测
Objective To compare the application of optical coherence tomography (OCT) to measure the thickness of retinal nerve fiber layer (RNFL) and the pattern electroretinogram (PERG) in the diagnosis and monitoring of open-angle glaucoma. Methods A pairwise study was performed. OCT and PERG were performed in 26 patients (50 eyes) with open-angle glaucoma. Pairedχ2 test was used to compare the two abnormalities in glaucoma. Linear regression analysis was used to analyze the correlation. Results The average thickness of RNFL in glaucoma around the optic disc and the RNFL thickness in the upper and lower quadrants were significantly correlated with the amplitude of PERG (P <0.05). The abnormal rates of OCT and PERG in early glaucoma were 40 9% and 77 9%, respectively, with significant difference (P <0.05); the rates of abnormalities in advanced stage and advanced stage were 78 6% and 82 1%, no significant difference. Conclusions In the early diagnosis of glaucoma, the sensitivity of OCT is lower than that of PERG. There is no significant difference in the sensitivity between OCT and PERG in advanced stage and advanced stage. Joint examination will be more conducive to the early diagnosis and monitoring of open-angle glaucoma