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Aim: To evaluate the use of free/total prostate specific antigen ratio (fPSA/tPSA ratio) in improving the early diagnosis of prostate cancer. Methods: The fPSA/tPSA ratio in the serum was analyzed in 187 men with tPSA ranging between 4.0 and 20.0 μg/L. All of them underwent ultrasound guided sextant prostatic biopsy. The results were calculated by SPSS 10.0 software. Results: (1) When the tPSA was within the ranges of 4.0 - 10.0 and 10.0 -20.0 μg/L, the prostate cancer detection rate was 18.1 % and 22.5 %, respectively; (2) The area under the curve (AUC) was bigger in fPSA/tPSA than in tPSA (P<0.05) in all the men; (3) When the cut off value of fPSA/tPSA ratio was set at 0.25 and the tPSA at 4.0 - 10.0 μg/L and 10.0 - 20.0 μg/L, the diagnostic sensitivity of tPSA was 90.5 % and 87.5 %, respectively. Thus at the tPSA ranges of 4.0 - 10.0 and 10.0 - 20.0 μg/L, 26.7 % and 11.3 % of biopsies could be avoided, respectively. Conclusion: The use of fPSA/tPSA ratio can improve the prostate cancer detection
Aim: To evaluate the use of free / total prostate specific antigen ratio (fPSA / tPSA ratio) in improving the early diagnosis of prostate cancer. Methods: The fPSA / tPSA ratio in the serum was analyzed in 187 men with tPSA ranging between 4.0 and 20.0 μg / L. All of them underwent ultrasound guided sextant prostatic biopsy. The results were calculated by SPSS 10.0 software. Results: (1) When the tPSA was within the ranges of 4.0 - 10.0 and 10.0 -20.0 μg / L, the prostate (2) The area under the curve (AUC) was bigger in fPSA / tPSA than in tPSA (P <0.05) in all the men; (3) When the cut off value The diagnostic sensitivity of tPSA was 90.5% and 87.5%, respectively. At the tPSA ranges of 4.0 - 10.0 and 10.0 - 20.0 μg / L, respectively and 10.0 - 20.0 μg / L, 26.7% and 11.3% of biopsies could be avoided, respectively. Conclusion: The use of fPSA / tPSA ratio can improve the prostat e cancer detection