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本文检测了十二指肠球部溃疡患者和慢性浅表性胃炎患者及正常人球、胃粘膜内肥大细胞和组胺的实验指标.结果显示治疗前球部溃疡活动期患者的肥大细胞病理形态改变与正常人有差别,与慢性胃炎患者也有程度上的不同;而且脱粒细胞数量高于正常人和慢性胃炎患者(P<0.001)。说明球部溃疡活动期患者球、胃粘膜内肥大细胞处于高度活化脱粒状态.治疗后溃汤愈合,肥大细胞由脱粒型转变为接近正常人的静止型细胞,脱粒细胞数量下降(P<0.001),部分组胺值高的患者治疗后组胺值下降(P<0.05).提示肥大细胞的病理形态学改变可能是球部溃疡重要的发病机制之一,同时部分球部溃疡患者的发病及愈合过程也可能与局部组胺含量增高变化有关。
This article examines duodenal ulcer patients and patients with chronic superficial gastritis and normal human, gastric mucosal mast cells and histamine experimental indicators.The results show that before treatment of ulcer activity in patients with mast cell pathological morphology Changes and normal differences, and patients with chronic gastritis are also somewhat different; and the number of degranulation cells than normal and chronic gastritis patients (P <0.001). The results showed that the ball and gastric mucosa of mast cells were highly active in degranulation and the mucosa of the gastric mucosa was activated by thrombus.When the ulcer was healed and the mast cells changed from thylakoid to quiescent cells close to normal, the number of degranulation cells decreased (P <0.001) (P <0.05), indicating that the histopathological changes of mast cells may be one of the important pathogenesis of ulceration of the ulcer, and the incidence and healing of some patients with ulceration of the bulb The process may also be related to changes in local histamine levels.