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目的：探讨多胺（ＰＡ）、ＣＡ１２５、ＣＡ１５．３和ＣＡ１９．９在定性诊断上皮性卵巢癌中的价值。方法：应用ＨＰ％Ｍ高效液相色谱仪和ＨＰ１０４０Ａ荧光检测器或酶联免疫吸附法测定上皮性卵巢癌４０例和卵巢良性肿瘤１８例血清中ＰＡ、ＣＡ１２５、ＣＡ１５．３和ＣＡ１９．９水平。结果：４种标志物中，ＰＡ诊断卵巢癌的敏感性、阳性预测率、阴性预测率和预测准确率最高，其次是ＣＡ１２５。结论：ＰＡ对人类恶性肿瘤缺乏特异性，但可作为鉴别卵巢良、恶性病变的有价值标志物。联合测定ＰＡ和ＣＡ１２５时，其敏感率为９４．９％。因此，联合测定ＰＡ和ＣＡ１２５可作为筛查卵巢良、恶性肿瘤的方法。
Objective: To investigate the value of polyamines (PA), CA125, CA15.3, and CA19.9 in the qualitative diagnosis of epithelial ovarian cancer. Methods: The levels of PA, CA125, CA15.3 and CA19.9 in serum of 40 cases of epithelial ovarian cancer and 18 cases of ovarian benign tumor were measured by HP%M HPLC and HP1040A fluorescence detector or enzyme-linked immunosorbent assay. Results: Among the 4 markers, the sensitivity, positive predictive rate, negative predictive rate, and predictive accuracy of PA in the diagnosis of ovarian cancer were highest, followed by CA125. Conclusion: PA lacks specificity for human malignant tumors, but it can be used as a valuable marker for distinguishing ovarian benign and malignant lesions. When combined determination of PA and CA125, the sensitivity rate was 94.9%. Therefore, combined determination of PA and CA125 can be used as a screening method for ovarian benign and malignant tumors.