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我们通过实验选择钾盐20mEq/L、异搏定1mg/L和心得安0.1mg/L为心脏停搏液的主要成分(简称“钾异心”停搏液)。本实验用豚鼠左心室乳头肌细胞跨膜电位和心肌兴奋性为指标,比较含“钾异心”台氏液和合高[K+]台氏液对心肌细胞的影响,每组10例,发现“钾异心”组能更快地使心肌兴奋性降到更低的水平,避免强大刺激诱发心肌动作电位产生;用台氏液灌洗后,两组心肌兴奋性恢复速度相似,半小时后“钾异心”组除动作电位时间仍明显延长外,刺激阈、静息电位和动作电位幅度均恢复实验前对照值水平。
We selected the experimental potassium 20mEq / L, verapamil 1mg / L and propranolol 0.1mg / L as the main component of cardiac cardioplegia (referred to as “potassium different heart” cardioplegia). In this experiment, the transmembrane potential and cardiac excitability of left ventricular papillary muscle cells of guinea pigs were used as an index to compare the effects of “different heterotrophic” Tyrosine solution and combined high [K +] Tyrode’s solution on cardiomyocytes in 10 patients in each group and found that “potassium Different heart ”group can make myocardial excitability to a lower level more quickly to avoid strong stimulation induced myocardial action potential; with Tyrodes solution lavage, the two groups of cardiac excitability recovery rate similar to half an hour after“ heterotrophic ”In addition to the group action potential time is still significantly longer, the stimulus threshold, resting potential and action potential amplitude were restored before the control level.