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目的:探讨~(131)I治联合丙硫氧嘧啶治疗对甲亢患者血清CT、PTH、BGP水平及甲状腺功能的影响。方法:甲亢患者80例随机分为观察组和对照组各40例。对照组使用~(131)I碘治疗,观察组在对照组基础上加用丙硫氧嘧啶。疗程均为2个月。观察两组患者治疗前后血清降钙素(CT)、甲状旁腺素(PTH)、骨钙素(BGP)及甲状腺功能各指标的变化,并记录不良反应。结果:治疗后,两组血清CT、PTH、BGP,以及甲状腺功能各指标水平均较治疗前得到改善(P<0.05);且观察组血清CT、BGP,血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)水平均低于对照组,血清PTH、促甲状腺激素(FSH)水平高于对照组(P<0.05)。两组患者药品不良反应发生率比较,差异无统计学意义(P>0.05)。结论:甲亢患者在~(131)I碘治疗的基础上加用丙硫氧嘧啶可以有效的降低血清CT、BGP的水平,使血清PTH水平增加,促进甲状腺功能得到恢复,值得推广应用。
Objective: To investigate the effect of ~ (131) I combined with propylthiouracil on serum CT, PTH, BGP levels and thyroid function in patients with hyperthyroidism. Methods: 80 hyperthyroidism patients were randomly divided into observation group and control group, 40 cases each. The control group was treated with ~ (131) I iodine, and the observation group was given propylthiouracil on the basis of the control group. Treatment are 2 months. The changes of serum calcitonin (CT), parathyroid hormone (PTH), osteocalcin (BGP) and thyroid function were observed before and after treatment. The adverse reactions were recorded. Results: After treatment, the levels of serum CT, PTH, BGP and thyroid function in both groups were improved compared with before treatment (P <0.05); and serum CT, BGP, serum free triiodothyronine FT4, TPOAb and TGAb were lower than those in the control group (P <0.05). Serum levels of PTH and thyroid stimulating hormone (FSH) were higher than those in the control group (P < 0.05). Two groups of patients with adverse drug reactions, the difference was not statistically significant (P> 0.05). CONCLUSIONS: Thiosterone supplementation with propylthiouracil in patients with hyperthyroidism can effectively reduce serum levels of CT and BGP, increase serum PTH and promote thyroid function, which is worth popularizing and applying.