【摘 要】
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Dear EditorMacroautophagy (hereafter referred to as autophagy) is a cellular adaptation to starvation,involving the vesicular sequestration of the long-lived cy
【机 构】
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State Key Laboratory of Mycology, Institute of Microbiology,Chinese Academy of Sciences, Beijing 100
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Dear EditorMacroautophagy (hereafter referred to as autophagy) is a cellular adaptation to starvation,involving the vesicular sequestration of the long-lived cytoplasmic proteins and organelles such as mitochondria (Klionsky and Emr,2000).However,it also results in cell death when overactivated (Edinger and Thompson,2004).Stresses which affect cellular homeostasis including changes in oxidation status,build-up of damaged organelles and misfolded proteins,and infection by pathogens,have also been shown to induce autophagy (Rabinowitz and White,2010).Besides,autophagy was found to be involved in cancer forTnation and progression.Depending on tumor type,stage,and cellular context,autophagy can play either anti-or pro-tumorigenic roles (Mancias and Kimmelman,2011).
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