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目的 了解含有质子泵抑制剂(PPI)兰索拉唑的短期三联疗法对幽门螺杆菌(HP)根治的效果、不良反应及溃疡愈合和复发情况。方法 对152例胃镜证实为消化性溃疡患者,经胃粘膜活检脲素酶法(clotest)测定HP,阳性者用PPI兰索拉唑30mgbid,阿莫西林500mgbid及克拉霉素500mgbid三联治疗7d,分别于治疗结束后的4周及6月。复查胃镜及clotest,并记录根治治疗的不良反应。结果 152例消化性溃疡患者中,141例(92.8%)HP测定阳性,治疗后4周复查时,HP根治率为95.5%,溃疡愈合率为92.2%,3%的病人出现轻度不良反应,且不影响治疗。治疗后6月复查,HP阴性率为93.0%,溃疡复发率为2.6%,且复发者HP测定均再次阳性。结论 短期三联HP根治疗法具有疗效高、不良反应小、耐受性好等优点。
Objective To investigate the effect of short-term triple therapy with proton pump inhibitor (PPI) lansoprazole on the radical cure of Helicobacter pylori (HP), adverse reactions and ulcer healing and recurrence. Methods Fifty-two patients with peptic ulcer confirmed by gastroscopy were enrolled in the study. The patients were diagnosed as clotest by gastric mucosa biopsy, 30 mg bid of lansoprazole PPI, 500 mg bid of amoxicillin and 500 mg bid of clarithromycin for 7 days respectively. Four weeks and six months after the end of treatment. Review endoscopy and clotest, and record the adverse effects of radical treatment. Results Of the 152 patients with peptic ulcer, 141 (92.8%) were positive for HP. After 4 weeks of treatment, the cure rate of HP was 95.5%, the healing rate of ulcer was 92.2%, mild adverse reactions occurred in 3% And does not affect the treatment. After 6 months of treatment, the negative rate of HP was 93.0% and the rate of ulcer recurrence was 2.6%, and the relapsers were both tested again. Conclusion Short-term triple therapy HP has the advantages of high efficacy, small adverse reactions, good tolerability and so on.