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机体局部或全身失控性炎症反应是急性肺损伤(acute lung injury,ALI)的重要病理生理特征。脂氧素(lipoxin,LX)是机体重要的促炎症缓解物质。气道上皮细胞是组成气道屏障和气道环境刺激首先受累的细胞,外界刺激和肺组织内异常的活性氧引起气道上皮损伤在ALI中扮演重要角色。本研究发现,LX稳定气道上皮细胞钙黏蛋白(E-cadherin)的表达保护其完整
Local or systemic uncontrolled inflammatory response is an important pathophysiological feature of acute lung injury (ALI). Lipoxin (LX) is an important proinflammatory substance in the body. Airway epithelial cells are the first cells involved in the formation of airway barrier and airway environment stimuli. External airway injury caused by external stimuli and abnormal reactive oxygen species in lung tissue play an important role in ALI. This study found that LX stable airway epithelial cell cadherin (E-cadherin) expression of the protection of its integrity