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目的探讨心肌速度梯度(MVG)技术在评价先天性甲状腺功能低下症(CH)患儿左心室收缩功能方面的应用价值。方法应用定量组织速度成像(QTV I)技术分析35名CH患儿(CH组)及年龄匹配的30名正常婴幼儿(对照组)左心室心肌各节段长轴和短轴方向上的速度曲线,测量收缩期峰值运动速度(Vs),计算长轴和短轴方向上收缩期心肌速度梯度MVG1、MVG2和MVG3等参数。结果 CH患儿左心室后间隔、后壁、前间隔各节段MVG1、MVG2及MVG3较对照组减低明显,差异有统计学意义(P<0.05);CH患儿左室前壁基底段MVG3较对照组减低,差异有统计学意义(P<0.05);侧壁、下壁及前壁各节段MVG1、MVG2两组之间比较差异无统计学意义(P>0.05)。前壁中间段及心尖段、下壁及侧壁各节段MVG3两组之间比较差异无统计学意义(P>0.05)。结论 CH患儿左心室长轴和短轴方向心肌局部收缩功能在一定程度上存在降低,为临床早期干预提供依据。
Objective To investigate the value of myocardial velocity gradient (MVG) in evaluating left ventricular systolic function in children with congenital hypothyroidism (CH). Methods The QTV I technique was used to analyze the velocity curves in the long axis and the short axis in each of 35 CH children and 30 age-matched infants (control group) , The peak systolic velocity (Vs) was measured and parameters such as MVG1, MVG2 and MVG3 were calculated in the systolic myocardial velocity gradient along the long axis and the short axis. Results The MVG1, MVG2 and MVG3 in the posterior septum, the posterior wall and the anterior septum in CH children were significantly lower than those in the control group (P <0.05). MVG3 in the basal segment of left anterior wall in CH children was significantly lower than that in the control group (P <0.05). There was no significant difference between MVG1 and MVG2 in lateral, inferior and anterior wall segments (P> 0.05). There was no significant difference between MVG3 in the middle segment of the anterior wall, the apical segment, the inferior wall and the lateral wall (P> 0.05). Conclusions Local LV systolic and diastolic myocardial systolic function of left ventricular in CH patients is reduced to a certain degree, which provides the basis for clinical early intervention.