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本研究以同一批志愿者为对象,先后观察了人体经皮肤、呼吸道和消化道接触氟化物后的吸收与排泄。结果提示,水中离子型氟化物不能经皮肤吸收;空气中氟靶物(包括气氟与尘氟)经呼吸道的吸收率均值为60.9％,95％可信区间为52.5～69.3％,并且该吸收率与呼吸频率呈负相关;饮水中氟化物经消化道的吸收率接近100％;膳食中氟化物经消化道吸收率均值为91％,95％可信区间为89.7～92.2％。每日总排氟量相当于每日总摄氟量的50％左右。我们认为这一比例与摄氟来源和摄氟量的大小无关。每日尿排氟量占总排氟比例受不同来源氟化物吸收率的影响,本实验条件下为78～91％。每日尿排氟量和每日每公斤体重体内保留氟量均与每日总摄氟量呈正相关,而不依赖于摄氟途径。提示无论经何种途径进入体内的氟化物,其代谢过程可能是一致的。
In this study, the same group of volunteers as the object, has observed the human body through the skin, respiratory and gastrointestinal exposure to fluoride absorption and excretion. The results showed that ionic fluoride in water could not be absorbed by the skin. The average respiratory absorption of fluoride targets (including fluoride and dust) in air was 60.9% and the 95% confidence interval was 52.5-69.3% The rate of absorption was negatively correlated with the respiratory rate. The absorption rate of fluoride in drinking water through the digestive tract was close to 100%. The mean fluoride absorption in the diet was 91% and the 95% confidence interval was 89.7-92.2%. Total daily discharge of fluorine is equivalent to about 50% of the total daily intake of fluorine. We think this ratio has nothing to do with the sources of fluorine and the amount of fluoride taken. Urinary fluorosis per day total fluoride emissions ratio by different sources of fluoride absorption rate of the experimental conditions of 78 to 91%. Daily urinary fluoride excretion and daily fluoride per kilogram of body weight retained in fluoride per day with a total positive correlation, and does not depend on fluoride intake. It suggests that the metabolic process may be the same regardless of the way into the body of fluoride.