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目的探讨醛固酮拮抗剂在治疗心力衰竭中的应用。方法通过螺内酯评价试验来解决“醛固酮逃逸”问题。结果安慰剂组死亡386例(46%),螺内酯组死亡284例(35%)。结论RALES试验的结果令为醛固酮拮抗剂进入心衰的一线用药提供了理论依据。
Objective To investigate the use of aldosterone antagonists in the treatment of heart failure. Methods Spirolactone evaluation test to solve the “aldosterone escape ” problem. Results 386 (46%) patients in the placebo group and 284 (35%) patients in the spironolactone group died. Conclusions The results of the RALES trial provide a theoretical basis for first-line use of aldosterone antagonists in heart failure.