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核工业的不断发展,超钚核素的生产、研究、应用范围随之扩大,而辐射危害问题也就越来越引起学者的重视。研究核工厂超钚核素操作人员细胞遗传学的剂量效应关系显得十分重要。 ~(241)Am作为一种超钚核素,主要积聚在肝和骨皮质,是高毒内照射核素。Mckay曾报道~(241)Am所致肝细胞染色体畸变率随累积剂量呈明显的线性增加的剂量效应关系,其RBE值比~(60)Co高出40倍。而关于~(241)Am诱发外周血淋巴细胞染色体畸变的研究
With the continuous development of the nuclear industry, the production, research and application of ultra-plutonium nuclides have expanded, and the problem of radiation hazards has drawn more and more attention from scholars. It is very important to study the dose-response relationship of cytogenetics of operators of plutonium nuclides in nuclear plants. ~ (241) Am is an ultra-plutonium nuclide that accumulates mainly in the liver and cortical bone. It is a highly toxic and internally irradiated nuclide. Mckay reported a dose-response relationship between ~ (241) Am-induced chromosome aberration and hepatocyte chromosome aberration, with a significantly linear increase in cumulative dose, with RBE values 40-fold higher than ~ (60) Co. And about ~ (241) Am induced peripheral blood lymphocyte chromosome aberration study