核不均一核糖核蛋白(hnRNP)家族是近年来研究较热的一组核内RNA结合蛋白,它们在许多方面参与肿瘤的发生、发展,其中hnRNP A1是对肿瘤生物学特性影响较大的hnRNP家族成员之一。目前的研究认为,hnRNP A1主要通过调节RNA表达、促进端粒延长、抑制细胞凋亡、促进细胞增殖等机制参与肿瘤的发生、发展。本文就hnRNP A1在肿瘤发病机制中的研究进展作一概述。 In recent years, the nuclear heterogeneous nuclear ribonucleoprotein (hnRNP) family is a hot group of nuclear RNA-binding proteins that are involved in many aspects of tumorigenesis and development. Among them, hnRNP A1 is a hnRNP that has a great influence on the biological characteristics of tumors One of the family members. The current study suggests that hnRNP A1 mainly participates in the occurrence and development of tumors by regulating RNA expression, promoting telomere elongation, inhibiting apoptosis and promoting cell proliferation. This article summarizes the progress of hnRNP A1 in the pathogenesis of cancer.