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目的 探讨老年癫痫病人的抗痫药浓度变化及诊治特点。方法 用HPLC方法或TDX分析仪测定血浓度。结果 老年性癫痫多为症状性癫痫 ,全身性发作的疗效优于部分性发作。服常规剂量 ,苯妥英钠、卡马西平及丙戊酸钠的血浓度范围分别为 :12 .1～ 5 1μg·ml- 1 ,3.5 4～ 15 .1μg·ml- 1 ,2 8～ 12 7μg·ml- 1 。出现不同程度的副作用 31例(37% )。结论 老年性癫痫的临床表现有别于青少年。对老年癫痫患者 ,应据其临床发作情况 ,有无药物不良反应 ,参考抗痫药浓度调整剂量。
Objective To investigate the changes of anti-epileptic drugs in elderly patients with epilepsy and its diagnosis and treatment characteristics. Methods The blood concentration was determined by HPLC method or TDX analyzer. Results Senile epilepsy mostly symptomatic epilepsy, systemic seizures better than partial seizures. The routine dose, phenytoin sodium, carbamazepine and sodium valproate blood concentration range were: 12 .1 ~ 5 1μg · ml-1, 3.54 ~ 15 .1μg · ml-1, 28 ~ 127μg · ml-1. There were 31 cases (37%) with varying degrees of side effects. Conclusion The clinical manifestations of senile epilepsy are different from those of adolescents. Elderly patients with epilepsy, should be based on their clinical seizures, with or without adverse drug reactions, reference dose of anti-epileptic drug concentration adjustment.