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目的比较单纯硬化剂与联合施他宁治疗肝硬变食管静脉曲张破裂出血的疗效与并发症。方法将 76例肝硬变食管静脉曲张破裂出血的患者随机分为两组。3 0例单纯使用硬化剂治疗 ,46例于硬化剂治疗前 15分钟先予施他宁 2 5 0μg,静脉注射 ,再给予 2 5 0μg/h维持静滴 2 4小时。结果单纯硬化剂组和联合施他宁组平均止血时间分别为 (15 .3± 4.4)小时和 (13 .6± 4.2 )小时 ;近期再出血率分别为 10 %和 6.5 % ;病死率分别为 6.7%及 0 % ;P均 >0 .0 5。注射硬化剂后针眼涌血发生率分别为 73 .3 %和 15 .2 % ,P<0 .0 5。结论单纯硬化剂与联合施他宁治疗肝硬变食管静脉曲张破裂出血的疗效相近 ,但联用施他宁组注射硬化剂后针眼涌血发生率明显低于单纯硬化治疗组 ,极大地提高了硬化治疗的安全性 ,同时缩短了操作时间
Objective To compare the efficacy and complications of simple sclerosing agent and combination of thalline in the treatment of hepatic cirrhosis esophageal variceal bleeding. Methods 76 patients with cirrhosis esophageal variceal bleeding were randomly divided into two groups. Thirty patients were treated with sclerotherapy alone. Forty-six patients were given shitamorene (250μg) 15 minutes before sclerotherapy, intravenous injection, and intravenous infusion of 250μg / h for 24 hours. Results The mean time to hemostasis was (15.3 ± 4.4) hours and (13.6 ± 4.2) hours respectively in the simple sclerostone group and the combination of thalidomide group. The rates of recent rebleeding were 10% and 6.5%, respectively. The mortality rates were 6.7% and 0% respectively; P> 0.05. The incidence of needle-hole bleeding after injection of sclerosant was 73.3% and 15.2%, respectively, P <0.05. Conclusions The curative effect of simple sclerosant and combination of shitamine on cirrhosis with esophageal variceal bleeding is similar, but the incidence of needle-hole bleeding is significantly lower than that of sclerotherapy group Sclerotherapy safety, while reducing operating time