论文部分内容阅读
目的：通过动物实验证实中药黄芪对顺铂所致肾毒性有防护作用，指导临床替代或部分替代水化，达到扩大大剂量顺铂适用范围的目的。方法：以７ｍｇ·ｋｇ－１顺铂单次ｉｐ建立小鼠的肾脏损伤模型，于实验的第１～７天分别给以不同剂量的黄芪ｉｐ。评估小鼠平均体重、平均尿量、血尿素氮、血肌酐、血ＮＡＧ酶及其肾脏病理学改变。同样的方法实验Ｓ１８０荷瘤小鼠，评估瘤重。结果：不同剂量的黄芪均能明显改善顺铂所致小鼠体重、尿量的减少及血尿素氮、血肌酐、血ＮＡＧ酶的增高，并获病理学支持能明显减轻顺铂所致肾损害，且对顺铂的抗瘤活性无影响。结论：黄芪能防护顺铂所致的肾毒性且不影响其抗瘤活性，值得临床进一步研究。
OBJECTIVE: To verify the efficacy of Astragalus membranaceus on cisplatin-induced nephrotoxicity through animal experiments, to guide clinical substitution or partial replacement hydration, and to expand the scope of application of high-dose cisplatin. Methods: A mouse kidney injury model was established with a single ip of 7 mg·kg-1 cisplatin. Different doses of jaundice ip were given on the first to seventh days of the experiment. Mean mouse body weight, mean urine volume, blood urea nitrogen, serum creatinine, blood NAG enzyme, and renal pathological changes were assessed. The same method was performed on S180 tumor-bearing mice to evaluate tumor weight. RESULTS: Different doses of Astragalus membranaceus could significantly improve the weight and urine volume of mice induced by cisplatin, increase blood urea nitrogen, serum creatinine, and blood NAG enzyme, and can significantly reduce kidney damage caused by cisplatin by pathological support. , and no effect on the anti-tumor activity of cisplatin. Conclusion: Astragalus can protect renal nephrotoxicity caused by cisplatin without affecting its anti-tumor activity. It is worthy of further study in clinic.