Background and Aims: Patients with cirrhosis are immu-nocompromised and at higher risk of developing infections compared to the general population. The aim of this study was to assess the incidence of infections in cirrhotic patients in a large academic liver center and investigate potential associations between infections, bacteria isolated, thera-peutic regimens used, and mortality. Methods: This was a retrospective chart review study, including 192 patients. All patients had a diagnosis of cirrhosis and were admitted to University Hospital. Information collected included demo-graphics, etiology of cirrhosis, identification of bacteria from cultures, multidrug-resistant (MDR) status, antibiotics ad-ministered, intensive care unit (ICU) admission, and patient mortality. Results: Infections were present in 105 (54.6％) patients, and 60 (31.2％) patients had multiple infections during a hospitalization(s) for infections. A total of 201 in-fections were identified. Urinary tract infections (UTIs) were the most common infection (37.8％), followed by bactere-mia (20.4％), pneumonia (12.9％), spontaneous bacterial peritonitis (SBP) (11.9％), abscess/cellulitis (6.0％), infec-tious diarrhea (6.0％), and other (5.0％). Escherichia coli was the most common bacteria isolated (13.4％), both among sensitive and MDR infections. MDR bacteria were the cause for 41.3％ of all infections isolated. Fungi accounted for 9.5％ of infections. 21.9％ of patients had decompen-sation from their infection(s) that required ICU care, and 14.6％ of patients died during hospitalization or soon after discharge. Conclusions: The incidence of infections in cir-rhotic patients is much higher than in their non-cirrhotic counterparts (54.6％), even higher than prior studies sug-gest. As many of these infections are caused by MDR bac-teria and fungal organisms, stronger empiric antibiotics and antifungals should be considered when initially treating thisimmunocompromised population. However, once organism sensitivities are discovered, narrowing of antibiotic regi-mens must occur to maintain good antibiotic stewardship.