论文部分内容阅读
内皮素-1(ET-1),是由内皮细胞产生的有效的收缩血管的多肽,主要通过肺的脉管系统降解,与各种组织的功能障碍的发病有关.为了弄清ET-1在成人呼吸窘迫综合征中的病理生理作用,及受损肺组织如何影响这种跨肺多肽物质的清除.我们比较了14例ARDS病人和7个作为对照的健康人的血浆和肺中ET-1的水平.为了在两组获得可比性,按0.4pmol/kg·min注射外源性ET-l到对照组中使之血浆浓度达9.4±0.8pmol/L,由于心输出量增加而总的血管阻力降低,
Endothelin-1 (ET-1), a potent vasoconstrictor polypeptide produced by endothelial cells, is mainly degraded by the vasculature of the lung and is associated with the development of dysfunction of various tissues. The pathophysiological role in adult respiratory distress syndrome and how impaired lung tissue affects clearance of this translocular peptide substance.We compared the plasma and lung ET-1 levels in 14 ARDS patients and 7 healthy controls In order to obtain comparability between the two groups, the exogenous ET-1 was injected into the control group at a concentration of 9.4 ± 0.8 pmol / L at a rate of 0.4 pmol / kg · min, and the total number of blood vessels Resistance is reduced,