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目的了解医院患者停乳链球菌感染特点及其耐药性,为临床合理应用抗菌药物提供科学依据。方法通过细菌分离鉴定技术和药敏试验方法,对2010-2012年某三甲医院培养出的457株停乳链球菌的临床分布及耐药性进行分析。结果该医院连续3年从患者送检标本中共检出停乳链球菌457株。分离标本居前3位依次是血液、分泌物和脓液,构成比分别为41.35%、20.13%和10.50%。停乳链球菌检出居前3位的科室分别是儿科重症监护病房(NICU)、皮肤科和综合重症监护病房(ICU),构成比依次为24.51%、20.35%和10.06%。临床分离的停乳链球菌对青霉素G、红霉素和氨苄西林的耐药率较高,对奎奴普汀、利奈唑胺和万古霉素全部敏感。结论该医院感染停乳链球菌的患者相对集中在儿科,耐药谱较宽,应加强停乳链球菌感染监测和药敏试验,提高抗菌药物合理使用率。
Objective To understand the characteristics and drug resistance of Streptococcus dysgalactiae in hospital patients and provide a scientific basis for rational use of antibacterials in clinic. Methods The clinical distribution and drug resistance of 457 strains of Streptococcus dysgalactiae cultured in a top three hospital from 2010 to 2012 were analyzed by bacterial isolation and identification techniques and drug susceptibility testing methods. Results The hospital detected 457 Streptococcus dysgalactiae from the patients for three consecutive years. The top three samples were blood, secretions and pus, with the proportions of 41.35%, 20.13% and 10.50%, respectively. The top three departments of S. dysgalactiae were the pediatric intensive care unit (NICU), dermatology department and integrated intensive care unit (ICU), with the proportions of 24.51%, 20.35% and 10.06%. Clinically isolated Streptococcus dysgalactiae has a higher rate of resistance to penicillin G, erythromycin and ampicillin and is entirely sensitive to quinuptin, linezolid and vancomycin. Conclusion The patients infected with Streptococcus dysgalactiae in this hospital are relatively concentrated in pediatrics, and the spectrum of drug resistance is relatively broad. Streptococcus suis should be strengthened to monitor the streptococcal infection and to increase its susceptibility to antibiotics.