二二三时代之前,防制疟疾的主要措施是填沟、排水、清渠,用油类或巴黎绿杀灭孑孓,应用食孑孓或食蚊鱼,空间喷洒除虫菊酯杀灭成蚊,以及使用抗疟药物治疗,首先用的是奎宁,30年代用阿的平。早在二十世纪初期 Gorgas 等在古巴、巴拿马及马来亚应用上述方法的综合措施获得成效的历史是众所周知的。但综合措施的费用,是高疟区发展中国家难以承担的。 Prior to the 2330s, the main measures against malaria were to fill ditches, drain water and clear channels, kill larvae with oil or Paris Green, apply larvae or mosquitoes, spray pyrethrins in space to kill adult mosquitoes, and use Antimalarial drug treatment, first with quinine, the 30’s with a flat. As early as the early twentieth century, Gorgas et al. Have notably obtained a history of the effectiveness of comprehensive measures applying the above methods in Cuba, Panama and Malaya. However, the costs of the comprehensive measures are unaffordable to developing countries in the high malarial region.