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HCG是主要由合体滋养层细胞分泌的一种糖蛋白激素,分子量为37000~38000,由α、β两个不同的亚基组成。α亚基的结构与腺垂体分泌的多种糖蛋白激素如卵泡刺激素、黄体生成素和促甲状腺激素等基本相似;β亚基决定了不同激素的生物活性,β-h CG与β-LH结构近似程度达80%,但β-h CG与β-LH差别主要示前者羧基端延长部分包含24个氨基酸,所以临床应用β-h CG亚基的特性作特异抗体用作诊断以避免干扰。h CG约在受精后第6天受精卵滋养层形成时开始微量分泌,由于h CG为水溶性容易被母体吸收入血,着床后用特异β-h CG抗血清即能在母血中检出。
HCG is a glycoprotein hormone secreted mainly by syncytiotrophoblasts, with a molecular mass of 37,000-38,000 and consists of two different subunits, alpha and beta. The structure of α subunit is similar to many glycoprotein hormones secreted by the pituitary gland, such as follicle stimulating hormone, luteinizing hormone and thyroid stimulating hormone. The β subunit determines the biological activity of different hormones. β-h CG and β-LH However, the difference between β-h CG and β-LH mainly shows that the former part of the carboxyl terminal extension contains 24 amino acids. Therefore, the characteristic of β-h CG subunit is used clinically as a diagnostic to avoid interference. h CG about the sixth day after fertilization fertilized egg trophoblast formation began to trace secretion, as hCG is easily absorbed by the mother into the water, after implantation, with specific beta-h CG antiserum that can be seized in maternal blood Out