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目的 :提高自体骨髓移植疗效 ,减少移植后疾病的复发。方法 :应用液体体外培养联合白细胞介素 2( IL -2 )激活的骨髓净化骨髓细胞 ,进行了 10例恶性血液病的自体骨髓移植 ( ABMT)。结果 :净化后骨髓有核细胞和CFU -GM的回收率分别为 49.8%和 3 6.4%。移植后所有患者均顺利地重建了骨髓造血功能 ,7例患者的中位持续完全缓解 ( CCR)时间达 2 7.6个月 ,2例患者移植后 10个月死于非病意外 ,1例 CCR7个月后死于白血病复发。结论 :液体培养联合 IL -2激活骨髓体外净化进行骨髓移植疗效好 ,白血病复发率低 ,方法简便
Objective: To improve the efficacy of autologous bone marrow transplantation and reduce the recurrence of diseases after transplantation. Methods: Marrow bone marrow cells were treated with IL-2 in combination with IL-2 in vitro and autologous bone marrow transplantation (ABMT) was performed in 10 patients with hematologic malignancies. Results: The recovery rates of purified bone marrow cells and CFU-GM were 49.8% and 34.4%, respectively. All patients successfully reconstructed the hematopoietic function of bone marrow after transplantation. The median duration of complete remission (CCR) in 7 patients reached 2 7.6 months, 2 patients died of non-disease 10 months after transplantation, and 1 CCR After the death of leukemia relapse. Conclusion: Liquid culture combined with IL-2 activated bone marrow purification of bone marrow transplantation has a good effect, leukemia recurrence rate is low, the method is simple