Synthesis, Crystal Structure and Antibacterial Activities of 3-[3-Methyl-(2-thienyl)methyl- enehydra

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The title compound, C9H9N5OS, was synthesized by the reaction of 3-(1H)-1,2,4 -triazole hydrazine with 3-methyl-2-thiophenecarboxaldehyde in ethanol. The single crystal struc- ture has been determined by X-ray diffraction analysis. The crystal belongs to monoclinic system, space group P21/n with a = 9.5550(10), b = 11.9847(12), c = 10.1074(11) ?, β = 112.995(2)°, V = 1065.47(19) ?3, Z = 4, μ = 0.290 mm-1, Mr = 235.27, Dc = 1.467 g/cm3 and F(000) = 488. The structure was solved by direct methods and refined to R = 0.0449. The crystal structure involves intermolecular hydrogen bonds of N–H…O and N–H…N as well as intramolecular hydrogen bond of N–H…N. Its biological activity has also been determined showing this type of compounds has certain antibacterial activity. The title compound, C9H9N5OS, was synthesized by the reaction of 3- (1H) -1,2,4 -triazole hydrazine with 3-methyl-2-thiophenecarboxaldehyde in ethanol. The single crystal structure has been determined by X-ray diffraction analysis. The crystal belongs to monoclinic system, space group P21 / n with a = 9.5550 (10), b = 11.9847 (12), c = 10.1074 (11)?,? = 112.995 (2) °, V = 1065.47 19 = 3, Z = 4, μ = 0.290 mm-1, Mr = 235.27, Dc = 1.467 g / cm3 and F (000) = 488. The structure was solved by direct methods and refined to R = Structure involves intermolecular hydrogen bonds of N-H ... O and N-H ... N as well as intramolecular hydrogen bond of N-H ... N. Its biological activity has also been determined showed this type of compounds has certain antibacterial activity.
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