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目的:探讨苯接触和慢性苯中毒患者外周血淋巴细胞亚群及T细胞水平的变化。方法:选取收治的慢性苯中毒患者16例和苯接触生产者20例,测定外周血淋巴细胞亚群分布和T细胞水平变化,探讨慢性苯中毒和长期低剂量苯接触对患者机体免疫系统造成的影响。结果:苯接触生产者与慢性苯中毒患者的总T细胞比例显著低于对照组,CD8T细胞比例显著高于对照组,P<0.05,苯接触者和慢性苯中毒患者外周血CD4T细胞比例、B细胞比例以及NK细胞比例,与对照组相比均呈逐渐降低趋势,但差异无统计学意义(P>0.05)。结论:早期检测外周血淋巴细胞亚群分布及变化有助于诊断和治疗。
Objective: To investigate the changes of peripheral blood lymphocyte subsets and T cells in patients with benzene exposure and chronic benzene poisoning. Methods: Twenty-six patients with chronic benzene poisoning and 20 benzene-exposed patients were enrolled in this study. Peripheral blood lymphocyte subsets and T cell levels were measured to investigate the effects of chronic benzene poisoning and prolonged low-dose benzene exposure on the body’s immune system influences. Results: The proportion of total T cells in benzene exposed patients and chronic benzene poisoning patients was significantly lower than that in control group, and the proportion of CD8 T cells was significantly higher than that in control group (P <0.05). The proportion of CD4 T cells in peripheral blood of benzene exposure patients and chronic benzene poisoning patients, B The proportion of cells and the proportion of NK cells decreased gradually compared with the control group, but the difference was not statistically significant (P> 0.05). Conclusion: The early detection of peripheral blood lymphocyte subsets distribution and changes help to diagnosis and treatment.