论文部分内容阅读
目的探讨肝硬化患者鼻出血的临床特征及相关危险因素。方法收集143例肝硬化患者的临床资料,其中鼻出血组75例,无鼻出血组(对照组)68例。分析指标包括性别、年龄、肝硬化病因学诊断、肝硬化分期、既往高血压史、鼻中隔偏曲、鼻腔干燥、血小板计数、活化部分凝血活酶时间、凝血酶原时间、纤维蛋白原,总胆红素。结果慢性乙型肝炎肝硬化最常见,鼻出血组占57.3%,对照组占52.9%。logistic回归分析结果显示,肝硬化分级(OR=6.272,95%CI 1.453~27.083,P=0.014)及鼻腔干燥(OR=4.286,95%CI 1.964~9.354,P<0.001)是导致肝硬化患者鼻出血发生的最主要因素。结论失代偿期肝硬化和鼻腔干燥是引发肝硬化患者发生鼻出血的重要危险因素。延缓肝硬化进程,保持鼻腔湿润状态,对减少肝硬化患者发生鼻出血具有重要意义。
Objective To investigate the clinical features and related risk factors of epistaxis in cirrhotic patients. Methods The clinical data of 143 patients with cirrhosis were collected, including 75 cases of nasal hemorrhage and 68 cases of non-nasal hemorrhage (control group). Analytical criteria included gender, age, etiologic diagnosis of cirrhosis, cirrhosis staging, previous history of hypertension, nasal septum deviation, nasal dryness, platelet count, activated partial thromboplastin time, prothrombin time, fibrinogen, total gall Red. Results Chronic hepatitis B cirrhosis was the most common, accounting for 57.3% in the nosebleed group and 52.9% in the control group. Logistic regression analysis showed that the grade of cirrhosis (OR = 6.272, 95% CI 1.453-27.083, P = 0.014) and nasal dryness (OR = 4.286, 95% CI 1.964-9.354, P <0.001) Bleeding the most important factor. Conclusions Decompensated cirrhosis and nasal dryness are important risk factors of nasal hemorrhage in cirrhotic patients. Delay the process of liver cirrhosis, keep nasal wet state, to reduce the occurrence of epistaxis in patients with cirrhosis of great significance.