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目的 研究血清涎酸 (SA)对贲门癌诊断及监测的临床价值。方法采用 Honda S改良的荧光测定法 ,对 115例贲门癌 ,85例良性疾病患者和 10 3例健康人进行血清 SA测定。结果 贲门癌组患者血清 SA含量显著高于良性疾病组和健康人组 (P<0 .0 1) ;以血清 SA水平大于 1.92×10 - 3 mol/L)为检测阳性 ,则对贲门癌诊断的敏感度、特异度、准确度依次为 83.5 %、89.4%、86 .0 % ;不同组织类型和临床分期的贲门癌患者血清 SA间也明显差异 ,血清 SA水平与肿瘤的分化程度和临床分期成正比 ;贲门癌根治术 4周后的血清 SA水平显著低于术前 (P<0 .0 1) ;贲门癌复发或有转移 ,则血清 SA再次明显升高或持续在高水平。结论 测定血清 SA对贲门癌诊断、疗效观察及术后监测具有显著的临床价值。
Objective To study the clinical value of serum citrate (SA) in the diagnosis and monitoring of cardiac cancer. Methods Serum SA was measured in 115 patients with cardiac cancer, 85 patients with benign disease, and 10 healthy subjects using Honda S modified fluorescence assay. Results Serum SA levels in patients with cardia cancer were significantly higher than those in benign disease group and healthy group (P<0.01). Serum SA levels greater than 1.92×10 -3 mol/L were positive for diagnosis of cardiac cancer. The sensitivity, specificity, and accuracy were 83.5 %, 89.4%, and 86.0%, respectively; there were also significant differences in serum SA between patients with different types of tissue and clinical stages of cardiac cancer, and serum SA levels and tumor differentiation and clinical stage. The proportion of serum SA after 4 weeks of radical gastrectomy was significantly lower than before surgery (P < 0.01). Recurrence or metastasis of cardiac cancer resulted in a marked increase in serum SA or continued high levels. Conclusion Determination of serum SA has significant clinical value in diagnosis, curative effect observation and postoperative monitoring of cardiac cancer.