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目的 :研究端粒酶在胃癌及其它胃疾病中的表达情况 ,以评价其临床诊断意义。方法 :采用TRAP法检测 32例胃癌 ,35例胃炎 ,8例肠上皮化生 ,8例胃溃疡 ,2例正常胃粘膜端粒酶活性。结果 :72 % (2 3/ 32 )胃癌组织 ,71% (2 5 / 35 )胃炎组织端粒酶呈阳性。肠上皮化生端粒酶呈阳性率为 5 / 8。 8例胃溃疡皆为端粒酶阴性。结论 :由于大多胃炎组织 (71% )端粒酶呈阳性 ,这将影响端粒酶在胃癌临床诊断中的应用。
Objective: To study the expression of telomerase in gastric cancer and other gastric diseases to evaluate its clinical significance. Methods : TRAP method was used to detect 32 cases of gastric cancer, 35 cases of gastritis, 8 cases of intestinal metaplasia, 8 cases of gastric ulcer, and 2 cases of normal gastric mucosa telomerase activity. Results: 72% (23/32) gastric cancer tissues and 71% (2 5 / 35) gastritis tissues were positive for telomerase. The positive rate of telomerase in intestinal metaplasia was 5 / 8. Eight gastric ulcers were all negative for telomerase. Conclusion: Since most of the gastritis tissues (71%) are positive for telomerase, this will affect the application of telomerase in the clinical diagnosis of gastric cancer.