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目的 :检测 cyclin D1 在膀胱移行细胞癌 (TCC)中的表达 ,探讨其与该肿瘤生物学行为的关系。方法 :应用免疫组化 SP法检测 45例膀胱 TCC和 12例正常膀胱 cyclin D1 组织的表达。结果 :膀胱 TCC组 cyclin D1 阳性表达率为 5 5 .5 6 % ,对照组无表达 ;临床分期 T0 ～ T1 为 78.5 % ,T2 ～ T4为 11.76 % ;肿瘤分级 G1 为 85 % ,G2 为46 .6 7% ,G3为 10 % ,随着肿瘤分期分级上升 ,阳性表达率逐渐升高 ;但在肿瘤初发和复发及单发和多发之间差异无显著性。结论 :cyclin D1 在膀胱 TCC形成的早期起重要的作用 ;在评估膀胱 TCC的生物学行为方面有着重要的临床意义
Objective : To detect the expression of cyclin D1 in bladder transitional cell carcinoma (TCC) and to explore its relationship with the biological behavior of the tumor. Methods : Immunohistochemical SP method was used to detect the expression of 45 cases of bladder TCC and 12 cases of normal bladder cyclin D1. Results: The positive expression rate of cyclin D1 in bladder TCC group was 55.56%. No expression was found in the control group. The clinical stage T0 ~ T1 was 78.5 %, T2 ~ T4 was 11.76 %; tumor grade G1 was 85%, G2 was 46. 6 7%, G3 was 10%. With the increase of tumor stage classification, the positive expression rate gradually increased. However, there was no significant difference in the initial and recurrence of tumors and between single and multiple tumors. Conclusion : Cyclin D1 plays an important role in the early formation of bladder TCC; it has important clinical significance in evaluating the biological behavior of bladder TCC