本文报道了低温均相和非均相Ｄａｗｓｓｏｎ型及Ｋｅｇｇｉｎ型杂多酸（盐）催化合成己二酸双丁酯的研究结果。提出了酯化反应的最佳条件。实验表明：杂多酸（盐）催化合成己二酸双丁酯的活性高、选择性好，产品质量也好。对催化机理进行了初步探讨。实验发现，杂多酸（盐）液相均相催化酯化是表型和体型催化反应的叠加，而在非均相催化酯化反应中，杂多阴离子无催化活性。 In this paper, we report the results of the catalytic synthesis of dibutyl adipate catalyzed by low-temperature homogeneous and heterogeneous Dawsson-type and Keggin-type heteropoly acid (salt). The optimal conditions of esterification were proposed. Experiments show that: heteropolyacid (salt) catalytic synthesis of dibutyl adipate high activity, good selectivity, product quality is also good. The catalytic mechanism was discussed. It was found that the heterogeneous catalysis of heteropolyacid (salt) liquid phase is superposition of phenotypic and bulk catalytic reactions, while heterogeneous anions have no catalytic activity in heterogeneous catalysis.