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美《医学论坛》第21卷第13期(1980年)报道佛罗里达州圣彼得斯堡消息:医生们给予老年病人抗心律不齐药物的剂量,往往低于适用量。宾夕法尼亚医学院药理学系主任罗伯茨(Jay Roberts)说,根据心脏中所见到的老化改变,才得出以上的结论。罗伯茨告诉本报说,“在动物研究中,我们已得到启示:老年人心脏对于抗心律不齐药物的反应缓慢,可减至2倍,因此,我们应该开始注意老年人用药的剂量,并应考虑提高奎尼丁和利多卡因的剂量”。
Volume 21, Issue 13 (1980) by the United States Medical Tribune St. Petersburg, Florida: The doses of anti-arrhythmic drugs given to older patients by doctors are often lower than those applied. Jay Roberts, director of the Department of Pharmacology at the Pennsylvania School of Medicine, said the above conclusion was reached based on the aging changes seen in the heart. Roberts told SciDev.Net that “in animal studies we have been inspired by the fact that the heart of the elderly responds slowly to antiarrhythmic drugs by a factor of two, so we should start to pay attention to the dose of the drug in the elderly and should Consider increasing the dose of quinidine and lidocaine. ”