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美国研究人员指出,端粒酶催化亚单位(人端粒酶逆转录酶,hTERT)的抑制在抗肿瘤疗法的研究发展中可能起着重要作用。在不表达端粒酶的正常细胞中,位于染色体末端的端粒DNA在连续的细胞分裂中逐渐地丧失。当端粒缩短到临界长度时,细胞增殖停止。在癌细胞中,端粒酶刺激端粒DNA的重新合成。因此,端粒不会缩短,细胞增殖以不受抑制的状态继续进行。
American researchers pointed out that inhibition of the telomerase catalytic subunit (human telomerase reverse transcriptase, hTERT) may play an important role in the development of anti-tumor therapy research. In normal cells that do not express telomerase, the telomere DNA located at the end of the chromosome is gradually lost in successive cell divisions. When the telomere shortens to a critical length, cell proliferation stops. In cancer cells, telomerase stimulates the resynthesis of telomere DNA. Therefore, telomeres will not be shortened, and cell proliferation proceeds in an uninhibited state.