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目的探讨双膦酸盐治疗高龄(>60岁)女性骨质疏松症对患者骨代谢的影响。方法选取确诊为骨质疏松的高龄女性患者120例,随机分为对照组(60例)与观察组(60例)两组,对照组给予迪巧补钙治疗,观察组给予双膦酸盐类药物治疗,比较两组患者治疗前后血钙、血磷、25羟基维生素D_3[(25-(OH)_2-D_3)]等钙磷指标及股骨颈骨密度、全髋骨密度、正位第1~4腰椎(L_(1~4))等骨密度(BMD)数值。结果两组患者治疗前血钙、血磷、25-(OH)_2-D_3及BMD含量比较差异未见统计学意义(P>0.05);对照组治疗前后血磷、25-(OH)_2-D_3含量差异有统计学意义,观察组较治疗前血钙、25-(OH)_2-D_3均显著上升,血磷含量显著下降,且均优于对照组,差异有统计学意义(P<0.05);对照组治疗后L_(1~4)BMD显著增高,较治疗前差异有统计学意义,观察组各BMD均显著增高,且治疗后较对照组差异有统计学意义(P<0.05)。结论双膦酸盐能提高高龄女性骨质疏松患者对钙的吸收代谢,增加骨密度。
Objective To investigate the effect of bisphosphonates on bone metabolism in elderly (> 60 years) female patients with osteoporosis. Methods A total of 120 elderly women with osteoporosis who were diagnosed as osteoporosis were randomly divided into two groups: control group (60 cases) and observation group (60 cases), while control group was treated with Diqiao calcium supplementation. The observation group was given bisphosphonates Before and after treatment, the levels of serum calcium, phosphorus and 25-hydroxyvitamin D 3 [(25- (OH) 2-D 3) and other calcium and phosphorus indexes and femoral neck BMD, total hip BMD, ~ 4 lumbar (L_ (1 ~ 4)) and other bone mineral density (BMD) values. Results The levels of serum calcium, phosphorus, 25- (OH) 2-D_3 and BMD were not significantly different between the two groups before treatment (P> 0.05) (P <0.05). There was significant difference in the content of D_3 between the observation group and the control group (P <0.05), the level of 25- (OH) 2-D_3 in the observation group increased significantly ). The BMD of L 1 (1-4) in the control group was significantly higher than that before treatment, and the BMD in the observation group was significantly higher than that of the control group (P <0.05). Conclusion Bisphosphonates can increase calcium absorption and metabolism in elderly women with osteoporosis and increase bone mineral density.