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硫酸奎尼丁是IA类抗心律失常药物,用于治疗心房颤动、心房扑动、室上性心动过速、房性早搏、室性早搏及室性心动过速.它能阻滞快钠通道,减慢动作电位0相上升速度,减慢激动在心房、心室及希-浦系统的传导速度,减低心肌兴奋性,抑制收缩性.奎尼丁主要通过肝脏代谢(80%～90%),约50%奎尼丁氧化物被肝脏微粒体细胞色素P450酶的同功酶CYP_3A_4所催化.由于P450酶尚能对其他药物发挥作用,因此预期许多药物可与奎尼丁发生相互作用.
Quinidine sulfate is an IA class antiarrhythmic drug used to treat atrial fibrillation, atrial flutter, supraventricular tachycardia, atrial premature beats, ventricular premature beats, and ventricular tachycardia. It blocks rapid sodium channels , Slow down the action potential 0 phase rising speed, slow down the activation in the atrium, ventricular and Greek-Pu system of conduction velocity, reduce cardiac excitability, inhibit contractility.Quinidine mainly through the liver metabolism (80% to 90%), About 50% of quinidine oxide is catalyzed by the CYP_3A_4 isoenzyme of liver microsomal cytochrome P450 enzymes, and many drugs are expected to interact with quinidine because P450 enzymes are still capable of acting on other drugs.